MP-412

别名】 MP-412; AV412; AV 412; MP412; MP 412

【CAS号】 451493-31-5

【纯度】 98%

【分子式】 C??H??ClFN?O?S?

【分子量】 851.41

【简介】 AV-412(MP-412, 2 tosylate salt) is a potent dual inhibitor of EGFR and ErbB2(IC50=19 nM) tyrosine kinases, including the mutant EGFR(L858R IC50=0.51 nM, T790M IC50=0.79 nM); inhibits autophosphorylation of EGFR and ErbB2 with IC(50) of 43 and 282 nM, resp