AZD8835

别名】 AZD 8835;AZD8835

【CAS号】 1620576-64-8

【纯度】 98%

【分子式】 C22H31N9O3

【分子量】 469.55

【简介】 AZD8835 is a selective, oral inhibitor of PI3K isoforms α and δ with the following activity in enzymatic assays: PI3K α – IC50 = 6nM (equipotent vs wt and E545K / H1047R mutants); PI3K δ – IC50 = 6nM; PI3K γ – IC50 = 90nM; PI3K β – IC50 = 431nM. Inhibition of signalling  in cells (pAKT endpoint): PI3K α – IC50= 57nM; PI3K δ – IC50= 49nM; PI3K β – IC50= 3.6μM; PI3K γ-  IC50= 532nM