AZD3759

分子量 459.9  

分子式 C22H23ClFN5O3

CAS号 1626387-80-1

AZD3759是一种有效的EGFR抑制剂, 抑制EGFR TK野生型, L858R 突变型, 和 Exon 19Del 酶的IC50值分别为0.3, 0.2, 和 0.2 nM。

AZD3759 is a potent, oral active, central nervous system-penetrant, EGFR inhibitor. At Km ATP concentrations, the IC50 values were 0.3, 0.2, and 0.2 nM for EGFR TK wild-type, L858R mutant, and Exon 19Del enzymes, respectively.